Publikační činnost

Publikační činnost autorů v Nemocnici Na Homolce je spravována Lékařskou knihovnou a zaznamenávána do vlastního evidenčního systému.

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Výsledky vědecko-výzkumné činnosti jsou zasílány poskytovateli dotace a následně evidovány v RIV (Rejstřík informací o výsledcích). Na základě těchto záznamu probíhá hodnocení, které slouží jako jeden z podkladů pro udělení institucionální podpory.

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Přehled výsledků výzkumné činnosti

Výběr odborných publikací autorů z Nemocnice Na Homolce

Review and current update of robotic-assisted laparoscopic vascular surgery

ŠTÁDLER, P. – DOROSH, J. – DVOŘÁČEK, L. – VITÁSEK, P. – MATOUŠ, P. a LIN, J. Review and current update of robotic-assisted laparoscopic vascular surgery. Seminars in Vascular Surgery. 2021, 34(4), s. 225-232. ISSN 0895-7967.

The field of vascular surgery is constantly evolving and is unsurpassed in its innovation and adoption of new technologies. Endovascular therapy has fundamentally changed the treatment paradigms for aneurysm and occlusive disease. As we continue to make advances in not only endovascular therapy, but also robotic surgery, artificial intelligence, and minimally invasive surgery, it is important that the vascular community stay at the forefront. Topics include the advantages of laparoscopic and robotic surgery over open surgery for aortic procedures, robotic versus laparoscopic aortic surgery, patient candidacy for robotic-assisted aortic surgery, and how to increase training and adoption of robotic-assisted laparoscopic aortic surgery. Future growth includes the development of new platforms and technologies, creation and validation of curriculum and virtual simulators, and conduction of randomized clinical trials to determine the best applications of robotics in vascular surgery.

Robust chitinolytic activity of crab-eating monkey (Macaca fascicularis) acidic chitinase under a broad pH and temperature range

UEHARA, M. – TABATA, E. – OKUDA, M. – MARUYAMA, Y. – MAŤOŠKA, V. – BAUER, P. a OYAMA, F. Robust chitinolytic activity of crab-eating monkey (Macaca fascicularis) acidic chitinase under a broad pH and temperature range. Scientific Reports. 2021, 11(1), 9 s. ISSN 2045-2322.

Diet of the crab-eating monkey (Macaca fascicularis) consists of both plants and animals, including chitin-containing organisms such as crabs and insects. This omnivorous monkey has a high expression of acidic chitinase (CHIA) in the stomach and here, we report on its enzymatic properties under different conditions. When we compared with Mus musculus CHIA (Mm-CHIA), Macaca fascicularis CHIA (Mf-CHIA) exhibits higher chitinolytic activity at broad pH (1.0-7.0) and temperature (30-70 ?) range. Interestingly, at its optimum pH (5.0), Mf-CHIA showed the highest activity at 65 degrees C while maintaining it at robust levels between 50 and 70 degrees C. The degradation efficiency of Mf-CHIA was superior to Mm-CHIA toward both polymeric chitin as well as an artificial chromogenic substrate. Our results show that unique features of Mf-CHIA including its thermostability warrant the nomination of this enzyme for potential agricultural and biomedical applications.